Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format.
نویسندگان
چکیده
We describe a method that enables specific and efficient conjugation of hydrazide-moieties to an IgG targeting the tumor neovasculature. The resulting chemically defined, homogeneous hydrazone-linked IgG conjugates remain immunoreactive and have a half-life of approximately 18 hours at physiological pH and temperature suitable for localized delivery of toxic drugs.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 56 شماره
صفحات -
تاریخ انتشار 2012